Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia Running title: Iriyama et al.; Placental adenosine signaling in preeclampsia
نویسندگان
چکیده
Depts of Biochemistry and Molecular Biology, The University of Texas-Houston Medical School, Houston, TX; Dept of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan; Graduate School of Biomedical Sciences, The University of Texas, Houston, TX; Depts of Urology, Xiangya Hospital of Central South University, Changsha, Hunan, China; Depts of Obstetrics, Gynecology and Reproductive Sciences, The University of Texas-Houston Medical School, Houston, TX; Depts of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Dept of Pathology, Texas Children’s Hospital, Houston, TX; Depts of Nephrology, Xiangya Hospital of Central South University, Changsha, Hunan, China
منابع مشابه
Letter by Escudero et al Regarding Article, "Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia".
BACKGROUND Preeclampsia is a prevalent hypertensive disorder of pregnancy and a leading cause of maternal and neonatal morbidity and mortality worldwide. This pathogenic condition is speculated to be caused by placental abnormalities that contribute to the maternal syndrome. However, the specific factors and signaling pathways that lead to impaired placentas and maternal disease development rem...
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Preeclampsia is a prevalent pregnancy hypertensive disease with both maternal and fetal morbidity and mortality. Emerging evidence indicates that global placental DNA hypomethylation is observed in patients with preeclampsia and is linked to altered gene expression and disease development. However, the molecular basis underlying placental epigenetic changes in preeclampsia remains unclear. Usin...
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Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial response to hypoxia, whereas chronically elevated HIF-1α is associated with multiple disease conditions, including preeclampsia, a serious hypertensive disease of pregnancy. However, the molecular basis underlying the persistent elevation of placental HIF-1α in preeclampsia and its role in the pathogenesis ...
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Preeclampsia, a prevalent hypertensive disorder of pregnancy, is believed to be secondary to uteroplacental ischemia. Accumulating evidence indicates that hypoxia-independent mediators, including inflammatory cytokines and growth factors, are associated with preeclampsia, but it is unclear whether these signals directly contribute to placental damage and disease development in vivo. We report t...
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C-reactive protein (CRP), an innate immune mediator, is elevated in the circulation before symptoms in patients with preeclampsia, a severe hypertensive pregnancy disorder with high mortality and morbidity. However, the specific sources underlying increased CRP and the role of elevated CRP in preeclampsia are undefined. Here, we report that circulating CRP levels are significantly increased in ...
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تاریخ انتشار 2014